Columbia University

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  • Genetic variant involved in determining C5a complement levels
  • This technology identifies a major genetic regulator of C5a complement levels. In a genome-wide association study, it was found that this particular genetic variant accounts for 36% increase in baseline C5a levels in healthy individuals. The variation was found to be common in Europeans and Asians, particularly South Central Asians, but absent in Africans. This novel variant could predict the magnitude of the immune response and therefore have implications for susceptibility to infection, septic shock syndrome, and renal diseases.
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  • DiagnosticMethods
  • New York, NY, United States
  • Columbia University
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  • Cervical Cancer Gene Markers for Targeted Therapy
  • Biomarkers Identified for Targeted, Personalized Cervical CancerTreatment This technology details a range of biomarkers that have been identified as being down-regulated in cervical cancer cells by genomic analysis of cervical cancer tissue and cell lines, as well as cytological pap smears. Specifically, these markers are related to the tumor necrosis factor (TNF) receptor superfamily pathway that plays a role in tumor cell apoptosis.
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  • DiagnosticMethods
  • New York, NY, United States
  • Columbia University
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