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  • Nitrosation-inducible Cytotoxins: A New Class of Therapeutics
  • Nitric oxide (•NO) is a free radical involved in numerousphysiological and pathological processes in mammals. NO is producedendogenously by a family of enzymes known as NO synthases (NOS). NO ischemically unreactive towards most bioorganic compounds, but it can rapidly andspontaneously auto-oxidize to yield the highly reactive species, N2O3, whichcovalently modifies (nitrosates) free thiol and amino groups. High levels of NOsynthesis and nitrosation are generally associated with immune response againstbacteria and viruses.
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  • TherapeuticsResearch materials
  • New York, NY, United States
  • New York University
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  • Fibrin Binding Peptides
  • Discovery of physical sites on Fn that bind to fibrin. The physical bindinginteraction between Fn and fibrin is critical to fibrin clot formation, as annecessary step in the wound repair process. Proteins, such as t-PA, that engagein fibrin binding have similar molecular structures however, the Fn dimer showsan affinity of two logs higher than any other fibrin-binding protein.
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  • TherapeuticsResearch materials
  • New York, NY, United States
  • New York University
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  • NZW mouse embryonic stem cells
  • New Zealand White (NZW) mice are used in research fields such as hematology, immunology and inflammation. F1 hybrids of NZB (New Zealand Black) and NZW are widely used as a model for autoimmunie diseases resembling human systemic lupus erythematosus. Establishing a novel NZW ES cell line therefore enables gene modiciation in ES cells and the creation of mouse models for autoimmune studies.
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  • Research materialsMethods
  • Palo Alto, CA, United States
  • Stanford University
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