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  • Gene therapy for inflammatory and autoimmune diseases
  • This technology comprises inhibitors of antibody production, including IgG, IgA and IgE. These peptide inhibitors are derived from naturally occurring mutations in the CRAF1 (TRAF-3) gene and they specifically inhibit CD40 mediated intracellular signaling. As the CD40-mediated signaling pathway is necessary for B-cell proliferation and antibody production, inhibitors of this pathway act as highly specific and effective immunosuppressants.
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  • TherapeuticsResearch materials
  • New York, NY, United States
  • Stanford University
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  • Parkinson's and Huntington's Treatment
  • This technology is an antisense oligonucleotide to the protein Nedd2. Nedd2 is an aspartase expressed by neuronal cells and plays a crucial role in apoptosis. When neurons are deprived of cytokines such as nerve growth factor (NGF), Nedd2 expression is upregulated as part of the apoptotic pathway. This technology is an antisense oligonucleotide (ANedd) capable of blocking expression of Nedd2, thereby inhibiting apoptosis.
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  • TherapeuticsResearch materials
  • New York, NY, United States
  • Stanford University
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  • siRNA Delivery to Inhibit Tumor Growth in the Central Nervous System
  • This invention provides compositions and methods that utilize a cell-permeable complex for facilitating the delivery of a double-stranded RNA into the central nervous system (CNS) to reduce the expression of a target protein, and in turn inhibit the growth of a tumor. Specifically, by convection-enhanced delivery to the CNS, a cell-permeable complex comprises a double stranded RNA that is effective in inhibiting the expression of the target protein, operably linked to a cell penetrating peptide.
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  • TherapeuticsResearch materials
  • New York, NY, United States
  • Stanford University
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  • Cancer Therapeutics Targeting Oncogenic-RAS- Expressing Tumor Cells
  • This technology describes methods for identifying an agent, which induces oxidative cell death in a tumor cell. The methods comprise determining the voltage dependent anion channel (VDAC) level in a tumor cell, and determining whether the tumor cell dies via oxidative cell death in the presence of a test agent. Furthermore, this technology provides a class of novel RAS-selective-lethal compounds capable of causing rapid and non-apoptotic cell death in oncogenic-RAS-expressing tumor cells.
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  • TherapeuticsResearch materials
  • New York, NY, United States
  • Columbia University
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  • DNA Methylation Profiling Method
  • The invention comprises new methods for profiling whole genome methylation by converting unmethylated cytosines in CpG dinucleotides to thymine analogues. Previous studies have shown that DNA methyltransferases can efficiently transfer a wide variety of functional groups to the 5 position of cytosines in DNA by means of synthetic S-Adenosyl L-methionine (AdoMet) analogs in which the methyl group has been replaced.
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  • Research materialsMethods
  • New York, NY, United States
  • Columbia University
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  • Nitrosation-inducible Cytotoxins: A New Class of Therapeutics
  • Nitric oxide (•NO) is a free radical involved in numerousphysiological and pathological processes in mammals. NO is producedendogenously by a family of enzymes known as NO synthases (NOS). NO ischemically unreactive towards most bioorganic compounds, but it can rapidly andspontaneously auto-oxidize to yield the highly reactive species, N2O3, whichcovalently modifies (nitrosates) free thiol and amino groups. High levels of NOsynthesis and nitrosation are generally associated with immune response againstbacteria and viruses.
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  • TherapeuticsResearch materials
  • New York, NY, United States
  • New York University
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  • Fibrin Binding Peptides
  • Discovery of physical sites on Fn that bind to fibrin. The physical bindinginteraction between Fn and fibrin is critical to fibrin clot formation, as annecessary step in the wound repair process. Proteins, such as t-PA, that engagein fibrin binding have similar molecular structures however, the Fn dimer showsan affinity of two logs higher than any other fibrin-binding protein.
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  • TherapeuticsResearch materials
  • New York, NY, United States
  • New York University
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  • NZW mouse embryonic stem cells
  • New Zealand White (NZW) mice are used in research fields such as hematology, immunology and inflammation. F1 hybrids of NZB (New Zealand Black) and NZW are widely used as a model for autoimmunie diseases resembling human systemic lupus erythematosus. Establishing a novel NZW ES cell line therefore enables gene modiciation in ES cells and the creation of mouse models for autoimmune studies.
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  • Research materialsMethods
  • Palo Alto, CA, United States
  • Stanford University
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