Discover innovations by
+ Research

Methods

Back
or
Back
Back
or
Back
Back
or
Back
Back
or
Back
  • Rapid in vitro analysis of force strain in cell signaling pathways for use in tissue engineering
  • Facile method allows direct observation of effect of force with much higher throughput than other methods. Other methods to apply force to proteins, such as AFM or optical tweezers, are limited by the difficulty of setting up experiments and the time to complete an analysis. Additionally, these instruments are very expensive and difficult to operate and maintain. This method allows for multiple measurements to be conducted at the same time, greatly increasing the rate of experiments that can be conducted by a single researcher.
  • Read more
  • Methods
  • New York, NY, United States
  • Stanford University
Back
or
Back
  • Binding Partner to Tumor Suppressor
  • HAUSP (herpesvirus-associated ubiquitin-specific protease) as a novel p53-interacting deubiquitinase. HAUSP strongly stabilizes p53 by deubiquitinating p53, even in the presence of excess Mdm2. In addition, HAUSP binds directly to Mdm2 in such a way as to form a three-protein complex with p53 and, via this indirect interaction, p53 is also stabilized. The technology provides methods for screening HAUSP-p53 and HAUSP-Mdm2 interactions.
  • Read more
  • TherapeuticsMethods
  • New York, NY, United States
  • Stanford University
Back
or
Back
Back
or
Back
Back
or
Back
  • DNA Methylation Profiling Method
  • The invention comprises new methods for profiling whole genome methylation by converting unmethylated cytosines in CpG dinucleotides to thymine analogues. Previous studies have shown that DNA methyltransferases can efficiently transfer a wide variety of functional groups to the 5 position of cytosines in DNA by means of synthetic S-Adenosyl L-methionine (AdoMet) analogs in which the methyl group has been replaced.
  • Read more
  • Research materialsMethods
  • New York, NY, United States
  • Columbia University
Back
or
Back
  • Treatment of Inherited and Genetic Cardiomyopathies by ERK Inhibition
  • This technology discovered that genes related to the ERK and JNK pathways exhibited statistically different expression at the incipience of the development of cardiomyopathies. Treatment with ERK inhibitor alone or treatment with both JNK inhibitor and ERK inhibitor significantly improved cardiac function assessed by echocardiography in EDMD mice. Activation of ERK or ERK plus JNK can lead to heart disease in EDMD and other inherited cardiomyopathies.
  • Read more
  • TherapeuticsMethods
  • New York, NY, United States
  • Columbia University
Back
or
Back
  • Diagnostic Biomarkers for Autism Spectrum Disorder
  • Early Detection of Autism Spectrum Disorder via Gastrointestinal and Genetic Biomarkers. This technology provides methods to detect autism spectrum disorders (ASD) earlier than current methods that rely on behavioral assessments and preclude diagnosis before three years of age. The authors have found elevated levels of a binding protein in the umbilical cord plasma of patients with autism spectrum disorder relative to control patients.
  • Read more
  • DiagnosticMethods
  • New York, NY, United States
  • Columbia University
Back
or
Back
Back
or
Back
Back
or
Back
Back
or
Back
Back
or
Back
Back
or
Back
Back
or
Back
  • Cervical Cancer Gene Markers for Targeted Therapy
  • Biomarkers Identified for Targeted, Personalized Cervical CancerTreatment This technology details a range of biomarkers that have been identified as being down-regulated in cervical cancer cells by genomic analysis of cervical cancer tissue and cell lines, as well as cytological pap smears. Specifically, these markers are related to the tumor necrosis factor (TNF) receptor superfamily pathway that plays a role in tumor cell apoptosis.
  • Read more
  • DiagnosticMethods
  • New York, NY, United States
  • Columbia University
Back
or
Back
  • Genetic variant involved in determining C5a complement levels
  • This technology identifies a major genetic regulator of C5a complement levels. In a genome-wide association study, it was found that this particular genetic variant accounts for 36% increase in baseline C5a levels in healthy individuals. The variation was found to be common in Europeans and Asians, particularly South Central Asians, but absent in Africans. This novel variant could predict the magnitude of the immune response and therefore have implications for susceptibility to infection, septic shock syndrome, and renal diseases.
  • Read more
  • DiagnosticMethods
  • New York, NY, United States
  • Columbia University
Back
or
Back
Back
or
Back
Back
or
Back
Back
or
Back
Back
or
Back
Back
or
Back
Back
or
Back
Back
or
Back
Back
or
Back
Back
or
Back
Back
or
Back
Back
or
Back
Back
or
Back
  • NZW mouse embryonic stem cells
  • New Zealand White (NZW) mice are used in research fields such as hematology, immunology and inflammation. F1 hybrids of NZB (New Zealand Black) and NZW are widely used as a model for autoimmunie diseases resembling human systemic lupus erythematosus. Establishing a novel NZW ES cell line therefore enables gene modiciation in ES cells and the creation of mouse models for autoimmune studies.
  • Read more
  • Research materialsMethods
  • Palo Alto, CA, United States
  • Stanford University
Back
or
Back
Back
or
Back
Back
or
Back
Back
or
Back
Back
or
Back
Back
or
Back
Back
or
Back
Back
or
Back
Back
or
Back
← Previous Next → 1 2 3 4 Last
Showing 1-40 from 232

Send Us a Message