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Diagnostic

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  • Diagnostic Biomarkers for Autism Spectrum Disorder
  • Early Detection of Autism Spectrum Disorder via Gastrointestinal and Genetic Biomarkers. This technology provides methods to detect autism spectrum disorders (ASD) earlier than current methods that rely on behavioral assessments and preclude diagnosis before three years of age. The authors have found elevated levels of a binding protein in the umbilical cord plasma of patients with autism spectrum disorder relative to control patients.
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  • DiagnosticMethods
  • New York, NY, United States
  • Columbia University
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  • Cervical Cancer Gene Markers for Targeted Therapy
  • Biomarkers Identified for Targeted, Personalized Cervical CancerTreatment This technology details a range of biomarkers that have been identified as being down-regulated in cervical cancer cells by genomic analysis of cervical cancer tissue and cell lines, as well as cytological pap smears. Specifically, these markers are related to the tumor necrosis factor (TNF) receptor superfamily pathway that plays a role in tumor cell apoptosis.
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  • DiagnosticMethods
  • New York, NY, United States
  • Columbia University
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  • Genetic variant involved in determining C5a complement levels
  • This technology identifies a major genetic regulator of C5a complement levels. In a genome-wide association study, it was found that this particular genetic variant accounts for 36% increase in baseline C5a levels in healthy individuals. The variation was found to be common in Europeans and Asians, particularly South Central Asians, but absent in Africans. This novel variant could predict the magnitude of the immune response and therefore have implications for susceptibility to infection, septic shock syndrome, and renal diseases.
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  • DiagnosticMethods
  • New York, NY, United States
  • Columbia University
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  • Beta-Amyloid Plaque Imaging Agents
  • An imaging agent and its derivatives for labelling β-amyloid plaques and NFTs that overcome these problems and also provide therapeutic properties in vivo for the neural tissues. The labelling agent also binds to norepinephrine transporters (NET) and are taken up into the cells via the NET, therefore serving as suitable agents for diagnostic and/or therapeutic purposes involving disorders or conditions associated with NET.
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  • TherapeuticsDiagnostic
  • Irvine, CA, United States
  • UC Irvine
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  • Specific Molecular Diagnostic Markers For Colon Cancer
  • Biomolecules that are potential diagnostic markers for colon cancer. These markers can be used singularly or combined, depending on the diagnostic testing need. There is increased flexibility for testing as a positive correlation is related to increased marker levels, decreased marker levels, or the presence of the molecule, depending on the biomarker.
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  • Diagnostic
  • Los Angeles, CA, United States
  • UC Los Angeles
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  • Novel Auditory Diagnostic
  • A novel method to assess the neural processing of auditory signals by creating experimental speech stimuli that can be used with both traditional and advanced techniques to analyze electrical brain activity. This new method provides a rapid, synoptic view into the functional health of the early auditory system, including how speech is processed at different levels and how these levels interact.
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  • DiagnosticMethods
  • Davis, CA, United States
  • UC Davis
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  • Diagnostic Colorimetric Assay
  • A simple yet highly selective and sensitive diagnostic tool along with new materials that can enable monitoring of copper levels in biological fluid samples without complex and expensive instrumentation. The diagnostic tool includes a robust three-dimensional porous aromatic framework (PAF) densely functionalized with thioether groups for selective capture and concentration of copper from biofluids as well as aqueous samples.
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  • DiagnosticMethods
  • Berkeley, CA, United States
  • UC Berkeley
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