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Tech Card

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  • Gene therapy for inflammatory and autoimmune diseases
  • This technology comprises inhibitors of antibody production, including IgG, IgA and IgE. These peptide inhibitors are derived from naturally occurring mutations in the CRAF1 (TRAF-3) gene and they specifically inhibit CD40 mediated intracellular signaling. As the CD40-mediated signaling pathway is necessary for B-cell proliferation and antibody production, inhibitors of this pathway act as highly specific and effective immunosuppressants.
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  • TherapeuticsResearch materials
  • New York, NY, United States
  • Stanford University
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  • Parkinson's and Huntington's Treatment
  • This technology is an antisense oligonucleotide to the protein Nedd2. Nedd2 is an aspartase expressed by neuronal cells and plays a crucial role in apoptosis. When neurons are deprived of cytokines such as nerve growth factor (NGF), Nedd2 expression is upregulated as part of the apoptotic pathway. This technology is an antisense oligonucleotide (ANedd) capable of blocking expression of Nedd2, thereby inhibiting apoptosis.
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  • TherapeuticsResearch materials
  • New York, NY, United States
  • Stanford University
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  • Rapid in vitro analysis of force strain in cell signaling pathways for use in tissue engineering
  • Facile method allows direct observation of effect of force with much higher throughput than other methods. Other methods to apply force to proteins, such as AFM or optical tweezers, are limited by the difficulty of setting up experiments and the time to complete an analysis. Additionally, these instruments are very expensive and difficult to operate and maintain. This method allows for multiple measurements to be conducted at the same time, greatly increasing the rate of experiments that can be conducted by a single researcher.
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  • Methods
  • New York, NY, United States
  • Stanford University
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  • Binding Partner to Tumor Suppressor
  • HAUSP (herpesvirus-associated ubiquitin-specific protease) as a novel p53-interacting deubiquitinase. HAUSP strongly stabilizes p53 by deubiquitinating p53, even in the presence of excess Mdm2. In addition, HAUSP binds directly to Mdm2 in such a way as to form a three-protein complex with p53 and, via this indirect interaction, p53 is also stabilized. The technology provides methods for screening HAUSP-p53 and HAUSP-Mdm2 interactions.
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  • TherapeuticsMethods
  • New York, NY, United States
  • Stanford University
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  • Treatment for Chronic Dry Eye Syndrome
  • Aqueous formulation of artificial tears based on the natural lipids of the meibomian secretions: Meibomian secretions are composed of a heterogenous lipid mixture, which forms a protective lipid surface that maintains the integrity of the tear film. This invention provides an aqueous formulation of artificial tears based on the natural lipids of the meibomian secretions.
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  • Therapeutics
  • New York, NY, United States
  • Stanford University
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  • siRNA Delivery to Inhibit Tumor Growth in the Central Nervous System
  • This invention provides compositions and methods that utilize a cell-permeable complex for facilitating the delivery of a double-stranded RNA into the central nervous system (CNS) to reduce the expression of a target protein, and in turn inhibit the growth of a tumor. Specifically, by convection-enhanced delivery to the CNS, a cell-permeable complex comprises a double stranded RNA that is effective in inhibiting the expression of the target protein, operably linked to a cell penetrating peptide.
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  • TherapeuticsResearch materials
  • New York, NY, United States
  • Stanford University
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  • Cancer Therapeutics Targeting Oncogenic-RAS- Expressing Tumor Cells
  • This technology describes methods for identifying an agent, which induces oxidative cell death in a tumor cell. The methods comprise determining the voltage dependent anion channel (VDAC) level in a tumor cell, and determining whether the tumor cell dies via oxidative cell death in the presence of a test agent. Furthermore, this technology provides a class of novel RAS-selective-lethal compounds capable of causing rapid and non-apoptotic cell death in oncogenic-RAS-expressing tumor cells.
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  • TherapeuticsResearch materials
  • New York, NY, United States
  • Columbia University
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  • DNA Methylation Profiling Method
  • The invention comprises new methods for profiling whole genome methylation by converting unmethylated cytosines in CpG dinucleotides to thymine analogues. Previous studies have shown that DNA methyltransferases can efficiently transfer a wide variety of functional groups to the 5 position of cytosines in DNA by means of synthetic S-Adenosyl L-methionine (AdoMet) analogs in which the methyl group has been replaced.
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  • Research materialsMethods
  • New York, NY, United States
  • Columbia University
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  • Treatment of Inherited and Genetic Cardiomyopathies by ERK Inhibition
  • This technology discovered that genes related to the ERK and JNK pathways exhibited statistically different expression at the incipience of the development of cardiomyopathies. Treatment with ERK inhibitor alone or treatment with both JNK inhibitor and ERK inhibitor significantly improved cardiac function assessed by echocardiography in EDMD mice. Activation of ERK or ERK plus JNK can lead to heart disease in EDMD and other inherited cardiomyopathies.
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  • TherapeuticsMethods
  • New York, NY, United States
  • Columbia University
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  • Diagnostic Biomarkers for Autism Spectrum Disorder
  • Early Detection of Autism Spectrum Disorder via Gastrointestinal and Genetic Biomarkers. This technology provides methods to detect autism spectrum disorders (ASD) earlier than current methods that rely on behavioral assessments and preclude diagnosis before three years of age. The authors have found elevated levels of a binding protein in the umbilical cord plasma of patients with autism spectrum disorder relative to control patients.
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  • DiagnosticMethods
  • New York, NY, United States
  • Columbia University
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  • Cervical Cancer Gene Markers for Targeted Therapy
  • Biomarkers Identified for Targeted, Personalized Cervical CancerTreatment This technology details a range of biomarkers that have been identified as being down-regulated in cervical cancer cells by genomic analysis of cervical cancer tissue and cell lines, as well as cytological pap smears. Specifically, these markers are related to the tumor necrosis factor (TNF) receptor superfamily pathway that plays a role in tumor cell apoptosis.
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  • DiagnosticMethods
  • New York, NY, United States
  • Columbia University
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  • Genetic variant involved in determining C5a complement levels
  • This technology identifies a major genetic regulator of C5a complement levels. In a genome-wide association study, it was found that this particular genetic variant accounts for 36% increase in baseline C5a levels in healthy individuals. The variation was found to be common in Europeans and Asians, particularly South Central Asians, but absent in Africans. This novel variant could predict the magnitude of the immune response and therefore have implications for susceptibility to infection, septic shock syndrome, and renal diseases.
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  • DiagnosticMethods
  • New York, NY, United States
  • Columbia University
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